2023
1: Zhou B, Zhou R, Chan JF, Zeng J, Zhang Q, Yuan S, Liu L, Robinot R, Shan S, Liu N, Ge J, Kwong HY, Zhou D, Xu H, Chan CC, Poon VK, Chu H, Yue M, Kwan KY, Chan CY, Chan CC, Chik KK, Du Z, Au KK, Huang H, Man HO, Cao J, Li C, Wang Z, Zhou J, Song Y, Yeung ML, To KK, Ho DD, Chakrabarti LA, Wang X, Zhang L, Yuen KY, Chen Z. SARS-CoV-2 hijacks neutralizing dimeric IgA for nasal infection and injury in Syrian hamsters1. Emerg Microbes Infect. 2023 Dec;12(2):2245921. doi: 10.1080/22221751.2023.2245921. PMID: 37542391; PMCID: PMC10444022.
2: Luo M, Zhou B, Reddem ER, Tang B, Chen B, Zhou R, Liu H, Liu L, Katsamba PS, Au KK, Man HO, To KK, Yuen KY, Shapiro L, Dang S, Ho DD, Chen Z. Structural insights into broadly neutralizing antibodies elicited by hybrid immunity against SARS-CoV-2. Emerg Microbes Infect. 2023 Dec;12(1):2146538. doi: 10.1080/22221751.2022.2146538. PMID: 36354024; PMCID: PMC9817130.
3: Yuen CK, Wong WM, Mak LF, Lam JY, Cheung LY, Cheung DT, Ng YY, Lee AC, Zhong N, Yuen KY, Kok KH. An interferon-integrated mucosal vaccine provides pan- sarbecovirus protection in small animal models. Nat Commun. 2023 Oct 24;14(1):6762. doi: 10.1038/s41467-023-42349-5. PMID: 37875475; PMCID: PMC10598001.
4: Lam JY, Wong WM, Yuen CK, Ng YY, San CH, Yuen KY, Kok KH. An RNA-Scaffold Protein Subunit Vaccine for Nasal Immunization. Vaccines (Basel). 2023 Sep 29;11(10):1550. doi: 10.3390/vaccines11101550. PMID: 37896953; PMCID: PMC10610892.
5: Shuai H, Chan JF, Hu B, Chai Y, Yoon C, Liu H, Liu Y, Shi J, Zhu T, Hu JC, Hu YF, Hou Y, Huang X, Yuen TT, Wang Y, Zhang J, Xia Y, Chen LL, Cai JP, Zhang AJ, Yuan S, Zhou J, Zhang BZ, Huang JD, Yuen KY, To KK, Chu H. The viral fitness and intrinsic pathogenicity of dominant SARS-CoV-2 Omicron sublineages BA.1, BA.2, and BA.5. EBioMedicine. 2023 Sep; 95:104753. doi: 10.1016/j.ebiom.2023.104753. Epub 2023 Aug 12. PMID: 37579626; PMCID: PMC10448076.
6: Chiu MC, Li C, Yu Y, Liu X, Huang J, Wan Z, Yuen KY, Zhou J. Establishing Bipotential Human Lung Organoid Culture System and Differentiation to Generate Mature Alveolar and Airway Organoids. Bio Protoc. 2023 Apr 20;13(8):e4657. doi: 10.21769/BioProtoc.4657. PMID: 37113328; PMCID: PMC10127040.
7: Li C, Huang J, Yu Y, Wan Z, Chiu MC, Liu X, Zhang S, Cai JP, Chu H, Li G, Chan JF, To KK, Yang Z, Jiang S, Yuen KY, Clevers H, Zhou J. Human airway and nasal organoids reveal escalating replicative fitness of SARS-CoV-2 emerging variants. Proc Natl Acad Sci U S A. 2023 Apr 25;120(17):e2300376120. doi: 10.1073/pnas.2300376120. Epub 2023 Apr 17. PMID: 37068258; PMCID: PMC10151566.
8: Deng S, Liu Y, Tam RC, Chen P, Zhang AJ, Mok BW, Long T, Kukic A, Zhou R, Xu H, Song W, Chan JF, To KK, Chen Z, Yuen KY, Wang P, Chen H. An intranasal influenza virus-vectored vaccine prevents SARS-CoV-2 replication in respiratory tissues of mice and hamsters. Nat Commun. 2023 Apr 12;14(1):2081. doi: 10.1038/s41467-023-37697-1. PMID: 37045873; PMCID: PMC10092940.
9: Chan JF, Huang X, Hu B, Chai Y, Shi H, Zhu T, Yuen TT, Liu Y, Liu H, Shi J, Wen L, Shuai H, Hou Y, Yoon C, Cai JP, Zhang AJ, Zhou J, Yin F, Yuan S, Zhang BZ, Brindley MA, Shi ZL, Yuen KY, Chu H. Altered host protease determinants for SARS-CoV-2 Omicron. Sci Adv. 2023 Jan 20;9(3):eadd3867. doi: 10.1126/sciadv.add3867. Epub 2023 Jan 20. PMID: 36662861; PMCID: PMC9858505.
10: Zhang R, Chan KH, Wang P, Zhou R, Yau HK, Wong CK, Au MW, Tam AR, Ng CT, Lou MK, Liu N, Huang H, Deng S, Tam RC, Liu Y, Long T, Tsoi HW, Ng MKW, Cai JP, To KK, Yuen MF, Chen Z, Chen H, Yuen KY, Hung IF. A Phase 1, Randomized, Double- Blinded, Placebo-Controlled and Dose-Escalation Study to Evaluate the Safety and Immunogenicity of the Intranasal DelNS1-nCoV-RBD LAIV for COVID-19 in Healthy Adults. Vaccines (Basel). 2023 Mar 24;11(4):723. doi: 10.3390/vaccines11040723. PMID: 37112634; PMCID: PMC10143096.
11: Cai JP, Luo C, Wang K, Cao H, Chen LL, Zhang X, Han Y, Yin F, Zhang AJ, Chu H, Yuan S, Kok KH, To KK, Chen H, Chen Z, Jin DY, Yuen KY, Chan JF. Intranasal Boosting with Spike Fc-RBD of Wild-Type SARS-CoV-2 Induces Neutralizing Antibodies against Omicron Subvariants and Reduces Viral Load in the Nasal Turbinate of Mice. Viruses. 2023 Mar 6;15(3):687. doi: 10.3390/v15030687. PMID: 36992395; PMCID: PMC10052291.
12: Zhou R, Liu N, Li X, Peng Q, Yiu CK, Huang H, Yang D, Du Z, Kwok HY, Au KK, Cai JP, Fan-Ngai Hung I, Kai-Wang To K, Xu X, Yuen KY, Chen Z. Three-dose vaccination-induced immune responses protect against SARS-CoV-2 Omicron BA.2: a population-based study in Hong Kong. Lancet Reg Health West Pac. 2023 Mar;32:100660. doi: 10.1016/j.lanwpc.2022.100660. Epub 2022 Dec 23. PMID: 36591327; PMCID: PMC9786166.
2022
1: Liu X, Li C, Wan Z, Chiu MC, Huang J, Yu Y, Zhu L, Cai JP, Rong L, Song YQ, Chu H, Cai Z, Jiang S, Yuen KY, Zhou J. Analogous comparison unravels heightened antiviral defense and boosted viral infection upon immunosuppression in bat organoids. Signal Transduct Target Ther. 2022 Dec 19;7(1):392. doi: 10.1038/s41392-022-01247-w. PMID: 36529763; PMCID: PMC9760641.
2: Zhao H, Meng X, Peng Z, Lam H, Zhang C, Zhou X, Chan JF, Kao RYT, To KK, Yuen KY. Fusion-inhibition peptide broadly inhibits influenza virus and SARS-CoV-2, including Delta and Omicron variants. Emerg Microbes Infect. 2022 Dec;11(1):926-937. doi: 10.1080/22221751.2022.2051753. PMID: 35259078; PMCID: PMC8973381.
3: Hu B, Chan JF, Liu H, Liu Y, Chai Y, Shi J, Shuai H, Hou Y, Huang X, Yuen TT, Yoon C, Zhu T, Zhang J, Li W, Zhang AJ, Zhou J, Yuan S, Zhang BZ, Yuen KY, Chu H. Spike mutations contributing to the altered entry preference of SARS-CoV-2 omicron BA.1 and BA.2. Emerg Microbes Infect. 2022 Dec;11(1):2275-2287. doi: 10.1080/22221751.2022.2117098. PMID: 36039901; PMCID: PMC9542985.
4: Wang P, Casner RG, Nair MS, Yu J, Guo Y, Wang M, Chan JF, Cerutti G, Iketani S, Liu L, Sheng Z, Chen Z, Yuen KY, Kwong PD, Huang Y, Shapiro L, Ho DD. A monoclonal antibody that neutralizes SARS-CoV-2 variants, SARS-CoV, and other sarbecoviruses. Emerg Microbes Infect. 2022 Dec;11(1):147-157. doi: 10.1080/22221751.2021.2011623. PMID: 34836485; PMCID: PMC8725896.
5: Poon RW, Chan BP, Chan WM, Fong CH, Zhang X, Lu L, Chen LL, Lam JY, Cheng VC, Wong SSY, Kok KH, Yuen KY, To KK. SARS-CoV-2 IgG seropositivity after the severe Omicron wave of COVID-19 in Hong Kong. Emerg Microbes Infect. 2022 Dec;11(1):2116-2119. doi: 10.1080/22221751.2022.2106899. PMID: 35880656; PMCID: PMC9448364.
6: Lam JY, Ng YY, Yuen CK, Wong WM, Yuen KY, Kok KH. A nasal omicron vaccine booster elicits potent neutralizing antibody response against emerging SARS- CoV-2 variants. Emerg Microbes Infect. 2022 Dec;11(1):964-967. doi: 10.1080/22221751.2022.2053365. PMID: 35275039; PMCID: PMC8973333.
7: Kok KH, Wong SC, Chan WM, Wen L, Chu AW, Ip JD, Lee LK, Wong IT, Lo HW, Cheng VC, Ho AY, Lam BH, Tse H, Lung D, Ng KNH, Au AK, Siu GK, Yuen KY. Co-circulation of two SARS-CoV-2 variant strains within imported pet hamsters in Hong Kong. Emerg Microbes Infect. 2022 Dec;11(1):689-698. doi: 10.1080/22221751.2022.2040922. PMID: 35135441; PMCID: PMC8890519.
8: Zhao H, Lu L, Peng Z, Chen LL, Meng X, Zhang C, Ip JD, Chan WM, Chu AW, Chan KH, Jin DY, Chen H, Yuen KY, To KK. SARS-CoV-2 Omicron variant shows less efficient replication and fusion activity when compared with Delta variant in TMPRSS2-expressed cells. Emerg Microbes Infect. 2022 Dec;11(1):277-283. doi: 10.1080/22221751.2021.2023329. PMID: 34951565; PMCID: PMC8774049.
9: Cao T, Liu L, To KK, Lim CY, Zhou R, Ming Y, Kwan KY, Yu S, Chan CY, Zhou B, Huang H, Mo Y, Du Z, Gong R, Yat LT, Hung IF, Tam AR, To WK, Leung WS, Chik TS, Tsang OT, Lin X, Song YQ, Yuen KY, Chen Z. Mitochondrial regulation of acute extrafollicular B-cell responses to COVID-19 severity. Clin Transl Med. 2022 Sep;12(9):e1025. doi: 10.1002/ctm2.1025. PMID: 36103567; PMCID: PMC9473490.
10: Chan JF, Hu B, Chai Y, Shuai H, Liu H, Shi J, Liu Y, Yoon C, Zhang J, Hu JC, Hou Y, Huang X, Yuen TT, Zhu T, Li W, Cai JP, Luo C, Yip CC, Zhang AJ, Zhou J, Yuan S, Zhang BZ, Huang JD, To KK, Yuen KY, Chu H. Virological features and pathogenicity of SARS-CoV-2 Omicron BA.2. Cell Rep Med. 2022 Sep 20;3(9):100743. doi: 10.1016/j.xcrm.2022.100743. Epub 2022 Aug 29. PMID: 36084644; PMCID: PMC9420712.
11: Chu H, Hou Y, Yang D, Wen L, Shuai H, Yoon C, Shi J, Chai Y, Yuen TT, Hu B, Li C, Zhao X, Wang Y, Huang X, Lee KS, Luo C, Cai JP, Poon VK, Chan CC, Zhang AJ, Yuan S, Sit KY, Foo DC, Au WK, Wong KK, Zhou J, Kok KH, Jin DY, Chan JF, Yuen KY. Coronaviruses exploit a host cysteine-aspartic protease for replication. Nature. 2022 Sep;609(7928):785-792. doi: 10.1038/s41586-022-05148-4. Epub 2022 Aug 3. PMID: 35922005.
12: Chiu MC, Li C, Liu X, Song W, Wan Z, Yu Y, Huang J, Xiao D, Chu H, Cai JP, To KK, Yuen KY, Zhou J. Human Nasal Organoids Model SARS-CoV-2 Upper Respiratory Infection and Recapitulate the Differential Infectivity of Emerging Variants. mBio. 2022 Aug 30;13(4):e0194422. doi: 10.1128/mbio.01944-22. Epub 2022 Aug 8. PMID: 35938726; PMCID: PMC9426414.
13: Lu L, Mok BWY, Chen LL, Chan JMC, Tsang OTY, Lam BHS, Chuang VWM, Chu AWH, Chan WM, Ip JD, Chan BPC, Zhang R, Yip CCY, Cheng VCC, Chan KH, Jin DY, Hung IFN, Yuen KY, Chen H, To KKW. Neutralization of Severe Acute Respiratory Syndrome Coronavirus 2 Omicron Variant by Sera From BNT162b2 or CoronaVac Vaccine Recipients. Clin Infect Dis. 2022 Aug 24;75(1):e822-e826. doi: 10.1093/cid/ciab1041. PMID: 34915551; PMCID: PMC8754807
14: Chan JFW, Poon VKM, Chan CCS, Chik KKH, Tsang JOL, Zou Z, Chan CCY, Lee ACY, Li C, Liang R, Cao J, Tang K, Yuen TTT, Hu B, Huang X, Chai Y, Shuai H, Luo C, Cai JP, Chan KH, Sridhar S, Yin F, Kok KH, Chu H, Zhang AJ, Yuan S, Yuen KY. Low Environmental Temperature Exacerbates Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Golden Syrian Hamsters. Clin Infect Dis. 2022 Aug 24;75(1):e1101-e1111. doi: 10.1093/cid/ciab817. PMID: 34536277.
15: Yuan S, Ye ZW, Liang R, Tang K, Zhang AJ, Lu G, Ong CP, Man Poon VK, Chan CC, Mok BW, Qin Z, Xie Y, Chu AW, Chan WM, Ip JD, Sun H, Tsang JO, Yuen TT, Chik KK, Chan CC, Cai JP, Luo C, Lu L, Yip CC, Chu H, To KK, Chen H, Jin DY, Yuen KY, Chan JF. Pathogenicity, transmissibility, and fitness of SARS-CoV-2 Omicron in Syrian hamsters. Science. 2022 Jul 22;377(6604):428-433. doi: 10.1126/science.abn8939. Epub 2022 Jun 23. PMID: 35737809.
16: Yan B, Yuan S, Cao J, Fung K, Lai PM, Yin F, Sze KH, Qin Z, Xie Y, Ye ZW, Yuen TT, Chik KK, Tsang JO, Zou Z, Chan CC, Luo C, Cai JP, Chan KH, Chung TW, Tam AR, Chu H, Jin DY, Hung IF, Yuen KY, Kao RY, Chan JF. Phosphatidic acid phosphatase 1 impairs SARS-CoV-2 replication by affecting the glycerophospholipid metabolism pathway. Int J Biol Sci. 2022 Jul 11;18(12):4744-4755. doi: 10.7150/ijbs.73057. PMID: 35874954; PMCID: PMC9305268.
17: Ye ZW, Fan Y, Tang K, Ong CP, Luo C, Chung HL, Leong TL, Liang R, Lui WY, Zhou R, Cheng Y, Lu L, Cheung PH, Chan JF, Chen Z, Yuen KY, Yuan S, To KK, Jin DY. Cross-variant protection against SARS-CoV-2 infection in hamsters immunized with monovalent and bivalent inactivated vaccines. Int J Biol Sci. 2022 Jul 13;18(12):4781-4791. doi: 10.7150/ijbs.72109. PMID: 35874942; PMCID: PMC9305277.
18: Chiu MC, Li C, Liu X, Yu Y, Huang J, Wan Z, Xiao D, Chu H, Cai JP, Zhou B, Sit KY, Au WK, Wong KK, Li G, Chan JF, To KK, Chen Z, Jiang S, Clevers H, Yuen KY, Zhou J. A bipotential organoid model of respiratory epithelium recapitulates high infectivity of SARS-CoV-2 Omicron variant. Cell Discov. 2022 Jun 17;8(1):57. doi: 10.1038/s41421-022-00422-1. PMID: 35710786; PMCID: PMC9203776.
19: Gao P, Wei Y, Wan RE, Wong KW, Iu HTV, Tai SSC, Li Y, Yam HCB, Halebeedu Prakash P, Chen JHK, Ho PL, Yuen KY, Davies J, Kao RYT. Subinhibitory Concentrations of Antibiotics Exacerbate Staphylococcal Infection by Inducing Bacterial Virulence. Microbiol Spectr. 2022 Aug 31;10(4):e0064022. doi: 10.1128/spectrum.00640-22. Epub 2022 Jun 27. PMID: 35758685; PMCID: PMC9431598.
20: hou B, Zhou R, Tang B, Chan JF, Luo M, Peng Q, Yuan S, Liu H, Mok BW, Chen B, Wang P, Poon VK, Chu H, Chan CC, Tsang JO, Chan CC, Au KK, Man HO, Lu L, To KK, Chen H, Yuen KY, Dang S, Chen Z. A broadly neutralizing antibody protects Syrian hamsters against SARS-CoV-2 Omicron challenge. Nat Commun. 2022 Jun 23;13(1):3589. doi: 10.1038/s41467-022-31259-7. PMID: 35739114; PMCID: PMC9223271.
21: Li C, Chen Y, Zhao Y, Lung DC, Ye Z, Song W, Liu FF, Cai JP, Wong WM, Yip CC, Chan JF, To KK, Sridhar S, Hung IF, Chu H, Kok KH, Jin DY, Zhang AJ, Yuen KY. Intravenous Injection of Coronavirus Disease 2019 (COVID-19) mRNA Vaccine Can Induce Acute Myopericarditis in Mouse Model. Clin Infect Dis. 2022 Jun 10;74(11):1933-1950. doi: 10.1093/cid/ciab707. Erratum in: Clin Infect Dis. 2021 Dec 16;73(12):2372-2373. PMID: 34406358; PMCID: PMC8436386.
22: Liu L, Iketani S, Guo Y, Reddem ER, Casner RG, Nair MS, Yu J, Chan JF, Wang M, Cerutti G, Li Z, Morano NC, Castagna CD, Corredor L, Chu H, Yuan S, Poon VK, Chan CC, Chen Z, Luo Y, Cunningham M, Chavez A, Yin MT, Perlin DS, Tsuji M, Yuen KY, Kwong PD, Sheng Z, Huang Y, Shapiro L, Ho DD. An antibody class with a common CDRH3 motif broadly neutralizes sarbecoviruses. Sci Transl Med. 2022 May 25;14(646):eabn6859. doi: 10.1126/scitranslmed.abn6859. Epub 2022 May 25. PMID: 35438546; PMCID: PMC9017343..
23: Ye ZW, Ong CP, Tang K, Fan Y, Luo C, Zhou R, Luo P, Cheng Y, Gray VS, Wang P, Chu H, Chan JF, To KK, Chen H, Chen Z, Yuen KY, Ling GS, Yuan S, Jin DY. Intranasal administration of a single dose of a candidate live attenuated vaccine derived from an NSP16-deficient SARS-CoV-2 strain confers sterilizing immunity in animals. Cell Mol Immunol. 2022 May;19(5):588-601. doi: 10.1038/s41423-022-00855-4. Epub 2022 Mar 29. PMID: 35352010; PMCID: PMC8961489.
24: Zhang R, Leung KY, Liu D, Fan Y, Lu L, Chan PC, To KK, Chen H, Yuen KY, Chan KH, Hung IF. Correlation of Immunogenicity and Reactogenicity of BNT162b2 and CoronaVac SARS-CoV-2 Vaccines. mSphere. 2022 Apr 27;7(2):e0091521. doi: 10.1128/msphere.00915-21. Epub 2022 Mar 14. PMID: 35285250; PMCID: PMC9044926.
25: Peng Q, Zhou R, Wang Y, Zhao M, Liu N, Li S, Huang H, Yang D, Au KK, Wang H, Man K, Yuen KY, Chen Z. Waning immune responses against SARS-CoV-2 variants of concern among vaccinees in Hong Kong. EBioMedicine. 2022 Mar;77:103904. doi: 10.1016/j.ebiom.2022.103904. Epub 2022 Mar 3. PMID: 35248996; PMCID: PMC8893246.
26: Lan Q, Chan JF, Xu W, Wang L, Jiao F, Zhang G, Pu J, Zhou J, Xia S, Lu L, Yuen KY, Jiang S, Wang Q. A Palmitic Acid-Conjugated, Peptide-Based pan-CoV Fusion Inhibitor Potently Inhibits Infection of SARS-CoV-2 Omicron and Other Variants of Concern. Viruses. 2022 Mar 6;14(3):549. doi: 10.3390/v14030549. PMID: 35336956; PMCID: PMC8955410.
27: Liu L, Iketani S, Guo Y, Chan JF, Wang M, Liu L, Luo Y, Chu H, Huang Y, Nair MS, Yu J, Chik KK, Yuen TT, Yoon C, To KK, Chen H, Yin MT, Sobieszczyk ME, Huang Y, Wang HH, Sheng Z, Yuen KY, Ho DD. Striking antibody evasion manifested by the Omicron variant of SARS-CoV-2. Nature. 2022 Feb;602(7898):676-681. doi: 10.1038/s41586-021-04388-0. Epub 2021 Dec 23. PMID: 35016198.
28: Mo Y, To KK, Zhou R, Liu L, Cao T, Huang H, Du Z, Lim CYH, Yim LY, Luk TY, Chan JM, Chik TS, Lau DP, Tsang OT, Tam AR, Hung IF, Yuen KY, Chen Z. Mitochondrial Dysfunction Associates With Acute T Lymphocytopenia and Impaired Functionality in COVID-19 Patients. Front Immunol. 2022 Jan 14;12:799896. doi: 10.3389/fimmu.2021.799896. PMID: 35095881; PMCID: PMC8795605.
29: Zhou R, To KK, Peng Q, Chan JM, Huang H, Yang D, Lam BH, Chuang VW, Cai JP, Liu N, Au KK, Tsang OT, Yuen KY, Chen Z. Vaccine-breakthrough infection by the SARS-CoV-2 omicron variant elicits broadly cross-reactive immune responses. Clin Transl Med. 2022 Jan;12(1):e720. doi: 10.1002/ctm2.720. PMID: 35083867; PMCID: PMC8792449.
30: Khong KW, Liu D, Leung KY, Lu L, Lam HY, Chen L, Chan PC, Lam HM, Xie X, Zhang R, Fan Y, To KK, Chen H, Yuen KY, Chan KH, Hung IF. Antibody Response of Combination of BNT162b2 and CoronaVac Platforms of COVID-19 Vaccines against Omicron Variant. Vaccines (Basel). 2022 Jan 21;10(2):160. doi: 10.3390/vaccines10020160. PMID: 35214619; PMCID: PMC8877145.
31: Zhang R, Liu D, Leung KY, Fan Y, Lu L, Chan PC, To KK, Chen H, Yuen KY, Chan KH, Hung IF. Immunogenicity of a Heterologous Prime-Boost COVID-19 Vaccination with mRNA and Inactivated Virus Vaccines Compared with Homologous Vaccination Strategy against SARS-CoV-2 Variants. Vaccines (Basel). 2022 Jan 3;10(1):72. doi: 10.3390/vaccines10010072. PMID: 35062734; PMCID: PMC8781520.
32: Zhou R, Wang P, Wong YC, Xu H, Lau SY, Liu L, Mok BW, Peng Q, Liu N, Woo KF, Deng S, Tam RC, Huang H, Zhang AJ, Zhou D, Zhou B, Chan CY, Du Z, Yang D, Au KK, Yuen KY, Chen H, Chen Z. Nasal prevention of SARS-CoV-2 infection by intranasal influenza-based boost vaccination in mouse models. EBioMedicine. 2022 Jan;75:103762. doi: 10.1016/j.ebiom.2021.103762. Epub 2021 Dec 21. PMID: 34942445; PMCID: PMC8687884.
2021
1: Zhang R, Khong KW, Leung KY, Liu D, Fan Y, Lu L, Chan PC, Chen L, To KK, Chen H, Yuen KY, Chan KH, Hung IF. Antibody Response of BNT162b2 and CoronaVac Platforms in Recovered Individuals Previously Infected by COVID-19 against SARS- CoV-2 Wild Type and Delta Variant. Vaccines (Basel). 2021 Dec 7;9(12):1442. doi: 10.3390/vaccines9121442. PMID: 34960189; PMCID: PMC8705363
2: Zhang BZ, Wang X, Yuan S, Li W, Dou Y, Poon VK, Chan CC, Cai JP, Chik KK, Tang K, Chan CC, Hu YF, Hu JC, Badea SR, Gong HR, Lin X, Chu H, Li X, To KK, Liu L, Chen Z, Hung IF, Yuen KY, Chan JF, Huang JD. A novel linker-immunodominant site (LIS) vaccine targeting the SARS-CoV-2 spike protein protects against severe COVID-19 in Syrian hamsters. Emerg Microbes Infect. 2021 Dec;10(1):874-884. doi: 10.1080/22221751.2021.1921621. PMID: 33890550; PMCID: PMC8118541.
3: Wang X, Lam JY, Chen L, Au SW, To KKW, Yuen KY, Kok KH. Mining of linear B cell epitopes of SARS-CoV-2 ORF8 protein from COVID-19 patients. Emerg Microbes Infect. 2021 Dec;10(1):1016-1023. doi: 10.1080/22221751.2021.1931465. PMID: 34003073; PMCID: PMC8186430.
4: Li C, Chen Y, Zhao Y, Christopher Lung D, Ye Z, Song W, Liu FF, Cai JP, Wong WM, Chik-YanYip C, Fuk-Woo Chan J, Kai-Wang To K, Sridhar S, Fan-Ngai Hung I, Chu H, Kok KH, Jin DY, JinxiaZhang A, Yuen KY. Corrigendum to: Intravenous Injection of Coronavirus Disease 2019 (COVID-19) mRNA Vaccine Can Induce Acute Myopericarditis in Mouse Model. Clin Infect Dis. 2021 Dec 16;73(12):2372-2373. doi: 10.1093/cid/ciab941. Erratum for: Clin Infect Dis. 2021 Aug 18;: PMID: 34849654; PMCID: PMC8690168.
5: Tse H, Lung DC, Wong SC, Ip KF, Wu TC, To KK, Kok KH, Yuen KY, Choi GK. Emergence of a Severe Acute Respiratory Syndrome Coronavirus 2 Virus Variant With Novel Genomic Architecture in Hong Kong. Clin Infect Dis. 2021 Nov 2;73(9):1696-1699. doi: 10.1093/cid/ciab198. PMID: 33675655; PMCID: PMC7989571.
6: Wang P, Casner RG, Nair MS, Yu J, Guo Y, Wang M, Chan JF, Cerutti G, Iketani S, Liu L, Sheng Z, Chen Z, Yuen KY, Kwong PD, Huang Y, Shapiro L, Ho DD. A monoclonal antibody that neutralizes SARS-CoV-2 variants, SARS-CoV, and other sarbecoviruses. bioRxiv [Preprint]. 2021 Oct 14:2021.10.13.464307. doi: 10.1101/2021.10.13.464307. Update in: Emerg Microbes Infect. 2021 Nov 26;:1-34. PMID: 34671769; PMCID: PMC8528075.
7: Mok BW, Liu H, Deng S, Liu J, Zhang AJ, Lau SY, Liu S, Tam RC, Cremin CJ, Ng TT, Leung JS, Lee LK, Wang P, To KK, Chan JF, Chan KH, Yuen KY, Siu GK, Chen H. Low dose inocula of SARS-CoV-2 Alpha variant transmits more efficiently than earlier variants in hamsters. Commun Biol. 2021 Sep 20;4(1):1102. doi: 10.1038/s42003-021-02640-x. PMID: 34545191; PMCID: PMC8452646.
8: Lee AC, Zhang AJ, Li C, Chen Y, Liu F, Zhao Y, Chu H, Fong CH, Wang P, Lau SY, To KK, Chen H, Yuen KY. Intradermal vaccination of live attenuated influenza vaccine protects mice against homologous and heterologous influenza challenges. NPJ Vaccines. 2021 Aug 4;6(1):95. doi: 10.1038/s41541-021-00359-8. PMID: 34349128; PMCID: PMC8339132.
9: Deng J, Zhang BZ, Chu H, Wang XL, Wang Y, Gong HR, Li R, Yang D, Li C, Dou Y, Gao P, Cai JP, Jin M, Du Q, Chan JF, Kao RY, Yuen KY, Huang JD. Adenosine synthase A contributes to recurrent Staphylococcus aureus infection by dampening protective immunity. EBioMedicine. 2021 Aug;70:103505. doi: 10.1016/j.ebiom.2021.103505. Epub 2021 Jul 28. PMID: 34332295; PMCID: PMC8340124.
10: Lai KK, Cheung NN, Yang F, Dai J, Liu L, Chen Z, Sze KH, Chen H, Yuen KY, Kao RYT. Correction for Lai et al., “Identification of Novel Fusion Inhibitors of Influenza A Virus by Chemical Genetics”. J Virol. 2021 Jul 12;95(15):e0066521. doi: 10.1128/JVI.00665-21. Epub 2021 Jul 12. Erratum for: J Virol. 2015 Dec 16;90(5):2690-701. PMID: 34251283; PMCID: PMC8274597.
11: >Zhou R, Wang P, Wong YC, Xu H, Lau SY, Liu L, Mok BW, Peng Q, Liu N, Woo KF, Deng S, Tam RC, Huang H, Zhang AJ, Zhou D, Zhou B, Chan CY, Du Z, Yang D, Au KK, Yuen KY, Chen H, Chen Z. Nasal prevention of SARS-CoV-2 infection by intranasal influenza-based boost vaccination in mouse models. EBioMedicine. 2022 Jan;75:103762. doi: 10.1016/j.ebiom.2021.103762. Epub 2021 Dec 21. PMID: 34942445; PMCID: PMC8687884.
12: Zhang Q, Ju B, Ge J, Chan JF, Cheng L, Wang R, Huang W, Fang M, Chen P, Zhou B, Song S, Shan S, Yan B, Zhang S, Ge X, Yu J, Zhao J, Wang H, Liu L, Lv Q, Fu L, Shi X, Yuen KY, Liu L, Wang Y, Chen Z, Zhang L, Wang X, Zhang Z. Potent and protective IGHV3-53/3-66 public antibodies and their shared escape mutant on the spike of SARS-CoV-2. Nat Commun. 2021 Jul 9;12(1):4210. doi: 10.1038/s41467-021-24514-w. PMID: 34244522; PMCID: PMC8270942.
13: Wong YC, Lau SY, Wang To KK, Mok BWY, Li X, Wang P, Deng S, Woo KF, Du Z, Li C, Zhou J, Chan JFW, Yuen KY, Chen H, Chen Z. Natural Transmission of Bat-like Severe Acute Respiratory Syndrome Coronavirus 2 Without Proline-Arginine- Arginine-Alanine Variants in Coronavirus Disease 2019 Patients. Clin Infect Dis. 2021 Jul 15;73(2):e437-e444. doi: 10.1093/cid/ciaa953. PMID: 32649739; PMCID: PMC7454488.
14: Zhang AJ, Lee AC, Chan JF, Liu F, Li C, Chen Y, Chu H, Lau SY, Wang P, Chan CC, Poon VK, Yuan S, To KK, Chen H, Yuen KY. Coinfection by Severe Acute Respiratory Syndrome Coronavirus 2 and Influenza A(H1N1)pdm09 Virus Enhances the Severity of Pneumonia in Golden Syrian Hamsters. Clin Infect Dis. 2021 Jun 15;72(12):e978-e992. doi: 10.1093/cid/ciaa1747. PMID: 33216851; PMCID: PMC7717201.
15: Chu H, Shuai H, Hou Y, Zhang X, Wen L, Huang X, Hu B, Yang D, Wang Y, Yoon C, Wong BH, Li C, Zhao X, Poon VK, Cai JP, Wong KK, Yeung ML, Zhou J, Au-Yeung RK, Yuan S, Jin DY, Kok KH, Perlman S, Chan JF, Yuen KY. Targeting highly pathogenic coronavirus-induced apoptosis reduces viral pathogenesis and disease severity. Sci Adv. 2021 Jun 16;7(25):eabf8577. doi: 10.1126/sciadv.abf8577. PMID: 34134991; PMCID: PMC8208716.
16: Wang P, Lau SY, Deng S, Chen P, Mok BW, Zhang AJ, Lee AC, Chan KH, Tam RC, Xu H, Zhou R, Song W, Liu L, To KK, Chan JF, Chen Z, Yuen KY, Chen H. Characterization of an attenuated SARS-CoV-2 variant with a deletion at the S1/S2 junction of the spike protein. Nat Commun. 2021 May 13;12(1):2790. doi: 10.1038/s41467-021-23166-0. PMID: 33986286; PMCID: PMC8119425.
17: To KK, Hung IF, Chan KH, Yuan S, To WK, Tsang DN, Cheng VC, Chen Z, Kok KH, Yuen KY. Serum Antibody Profile of a Patient With Coronavirus Disease 2019 Reinfection. Clin Infect Dis. 2021 May 18;72(10):e659-e662. doi: 10.1093/cid/ciaa1368. PMID: 32966566; PMCID: PMC7543314.
18: Zhou D, Chan JF, Zhou B, Zhou R, Li S, Shan S, Liu L, Zhang AJ, Chen SJ, Chan CC, Xu H, Poon VK, Yuan S, Li C, Chik KK, Chan CC, Cao J, Chan CY, Kwan KY, Du Z, Lau TT, Zhang Q, Zhou J, To KK, Zhang L, Ho DD, Yuen KY, Chen Z. Robust SARS-CoV-2 infection in nasal turbinates after treatment with systemic neutralizing antibodies. Cell Host Microbe. 2021 Apr 14;29(4):551-563.e5. doi: 10.1016/j.chom.2021.02.019. Epub 2021 Feb 25. PMID: 33657424; PMCID: PMC7904446.
19: Yang F, Pang B, Lai KK, Cheung NN, Dai J, Zhang W, Zhang J, Chan KH, Chen H, Sze KH, Zhang H, Hao Q, Yang D, Yuen KY, Kao RY. Discovery of a Novel Specific Inhibitor Targeting Influenza A Virus Nucleoprotein with Pleiotropic Inhibitory Effects on Various Steps of the Viral Life Cycle. J Virol. 2021 Apr 12;95(9):e01432-20. doi: 10.1128/JVI.01432-20. PMID: 33627391; PMCID: PMC8104107.
20: Wong SC, Chan VWM, Lam GK, AuYeung CH, Leung EY, So SY, Chen JH, Sridhar S, Tam AR, Hung IF, Ho PL, Yuen KY, Cheng VC. The use of multi-pronged screening strategy to understand the epidemiology of carbapenemase-producing Enterobacteriaceae in Hong Kong: transition from epidemic to endemic setting. Eur J Clin Microbiol Infect Dis. 2021 Sep;40(9):2017-2022. doi: 10.1007/s10096-021-04173-x. Epub 2021 Mar 5. PMID: 33666789.
21: Wang X, Lin X, Zheng Z, Lu B, Wang J, Tan AH, Zhao M, Loh JT, Ng SW, Chen Q, Xiao F, Huang E, Ko KH, Huang Z, Li J, Kok KH, Lu G, Liu X, Lam KP, Liu W, Zhang Y, Yuen KY, Mak TW, Lu L. Host-derived lipids orchestrate pulmonary γδ T cell response to provide early protection against influenza virus infection. Nat Commun. 2021 Mar 26;12(1):1914. doi: 10.1038/s41467-021-22242-9. PMID: 33772013; PMCID: PMC7997921.
22: Lau SKP, Fan RYY, Zhu L, Li KSM, Wong ACP, Luk HKH, Wong EYM, Lam CSF, Lo GCS, Fung J, He Z, Fok FCH, Au-Yeung RKH, Zhang L, Kok KH, Yuen KY, Woo PCY. Isolation of MERS-related coronavirus from lesser bamboo bats that uses DPP4 and infects human-DPP4-transgenic mice. Nat Commun. 2021 Jan 11;12(1):216. doi: 10.1038/s41467-020-20458-9. PMID: 33431849; PMCID: PMC7801609.
23: Chu H, Hu B, Huang X, Chai Y, Zhou D, Wang Y, Shuai H, Yang D, Hou Y, Zhang X, Yuen TT, Cai JP, Zhang AJ, Zhou J, Yuan S, To KK, Chan IH, Sit KY, Foo DC, Wong IY, Ng AT, Cheung TT, Law SY, Au WK, Brindley MA, Chen Z, Kok KH, Chan JF, Yuen KY. Host and viral determinants for efficient SARS-CoV-2 infection of the human lung. Nat Commun. 2021 Jan 8;12(1):134. doi: 10.1038/s41467-020-20457-w. PMID: 33420022; PMCID: PMC7794309.
2020
1: Liu L, To KK, Chan KH, Wong YC, Zhou R, Kwan KY, Fong CH, Chen LL, Choi CY, Lu L, Tsang OT, Leung WS, To WK, Hung IF, Yuen KY, Chen Z. High neutralizing antibody titer in intensive care unit patients with COVID-19. Emerg Microbes Infect. 2020 Dec;9(1):1664-1670. doi: 10.1080/22221751.2020.1791738. PMID: 32618497; PMCID: PMC7473321.
2: Chan JF, Zhang AJ, Yuan S, Poon VK, Chan CC, Lee AC, Chan WM, Fan Z, Tsoi HW, Wen L, Liang R, Cao J, Chen Y, Tang K, Luo C, Cai JP, Kok KH, Chu H, Chan KH, Sridhar S, Chen Z, Chen H, To KK, Yuen KY. Simulation of the Clinical and Pathological Manifestations of Coronavirus Disease 2019 (COVID-19) in a Golden Syrian Hamster Model: Implications for Disease Pathogenesis and Transmissibility. Clin Infect Dis. 2020 Dec 3;71(9):2428-2446. doi: 10.1093/cid/ciaa325. PMID: 32215622; PMCID: PMC7184405.
3: Lu L, Fong CH, Zhang AJ, Wu WL, Li IC, Lee AC, Dissanayake TK, Chen L, Hung IF, Chan KH, Chu H, Kok KH, Yuen KY, To KK. Repurposing of Miltefosine as an Adjuvant for Influenza Vaccine. Vaccines (Basel). 2020 Dec 11;8(4):754. doi: 10.3390/vaccines8040754. PMID: 33322574; PMCID: PMC7768360.
4: Lam JY, Yuen CK, Ip JD, Wong WM, To KK, Yuen KY, Kok KH. Loss of orf3b in the circulating SARS-CoV-2 strains. Emerg Microbes Infect. 2020 Dec;9(1):2685-2696. doi: 10.1080/22221751.2020.1852892. PMID: 33205709; PMCID: PMC7782295.
5: Liu L, Lin Q, Peng J, Fang J, Tan Z, Tang H, Kwan K, Nishiura K, Liang J, Kwok H, Du Z, Sun J, Liu K, Yuen KY, Wang H, Chen Z. Persistent lentivirus infection induces early myeloid suppressor cells expansion to subvert protective memory CD8 T cell response✰,✰✰. EBioMedicine. 2020 Oct;60:103008. doi: 10.1016/j.ebiom.2020.103008. Epub 2020 Sep 24. PMID: 32979832; PMCID: PMC7519271.
6: Zhou R, To KK, Wong YC, Liu L, Zhou B, Li X, Huang H, Mo Y, Luk TY, Lau TT, Yeung P, Chan WM, Wu AK, Lung KC, Tsang OT, Leung WS, Hung IF, Yuen KY, Chen Z. Acute SARS-CoV-2 Infection Impairs Dendritic Cell and T Cell Responses. Immunity. 2020 Oct 13;53(4):864-877.e5. doi: 10.1016/j.immuni.2020.07.026. Epub 2020 Aug 4. PMID: 32791036; PMCID: PMC7402670
7: Hung IF, Cheng VC, Li X, Tam AR, Hung DL, Chiu KH, Yip CC, Cai JP, Ho DT, Wong SC, Leung SS, Chu MY, Tang MO, Chen JH, Poon RW, Fung AY, Zhang RR, Yan EY, Chen LL, Choi CY, Leung KH, Chung TW, Lam SH, Lam TP, Chan JF, Chan KH, Wu TC, Ho PL, Chan JW, Lau CS, To KK, Yuen KY. SARS-CoV-2 shedding and seroconversion among passengers quarantined after disembarking a cruise ship: a case series. Lancet Infect Dis. 2020 Sep;20(9):1051-1060. doi: 10.1016/S1473-3099(20)30364-9. Epub 2020 Jun 12. PMID: 32539986; PMCID: PMC7292581.
8: Yuan S, Chu H, Huang J, Zhao X, Ye ZW, Lai PM, Wen L, Cai JP, Mo Y, Cao J, Liang R, Poon VK, Sze KH, Zhou J, To KK, Chen Z, Chen H, Jin DY, Chan JF, Yuen KY. Viruses harness YxxØ motif to interact with host AP2M1 for replication: A vulnerable broad-spectrum antiviral target. Sci Adv. 2020 Aug 28;6(35):eaba7910. doi: 10.1126/sciadv.aba7910. PMID: 32923629; PMCID: PMC7455044..
9: Liu L, Wang P, Nair MS, Yu J, Rapp M, Wang Q, Luo Y, Chan JF, Sahi V, Figueroa A, Guo XV, Cerutti G, Bimela J, Gorman J, Zhou T, Chen Z, Yuen KY, Kwong PD, Sodroski JG, Yin MT, Sheng Z, Huang Y, Shapiro L, Ho DD. Potent neutralizing antibodies against multiple epitopes on SARS-CoV-2 spike. Nature. 2020 Aug;584(7821):450-456. doi: 10.1038/s41586-020-2571-7. Epub 2020 Jul 22. PMID: 32698192.
10: To KK, Cheng VC, Cai JP, Chan KH, Chen LL, Wong LH, Choi CY, Fong CH, Ng AC, Lu L, Luo CT, Situ J, Chung TW, Wong SC, Kwan GS, Sridhar S, Chan JF, Fan CY, Chuang VWM, Kok KH, Hung IF, Yuen KY. Seroprevalence of SARS-CoV-2 in Hong Kong and in residents evacuated from Hubei province, China: a multicohort study. Lancet Microbe. 2020 Jul;1(3):e111-e118. doi: 10.1016/S2666-5247(20)30053-7. Epub 2020 Jun 3. PMID: 33230504; PMCID: PMC7673299.
11: Zhou J, Li C, Liu X, Chiu MC, Zhao X, Wang D, Wei Y, Lee A, Zhang AJ, Chu H, Cai JP, Yip CC, Chan IH, Wong KK, Tsang OT, Chan KH, Chan JF, To KK, Chen H, Yuen KY. Infection of bat and human intestinal organoids by SARS-CoV-2. Nat Med. 2020 Jul;26(7):1077-1083. doi: 10.1038/s41591-020-0912-6. Epub 2020 May 13. PMID: 32405028..
12: To KK, Tsang OT, Leung WS, Tam AR, Wu TC, Lung DC, Yip CC, Cai JP, Chan JM, Chik TS, Lau DP, Choi CY, Chen LL, Chan WM, Chan KH, Ip JD, Ng AC, Poon RW, Luo CT, Cheng VC, Chan JF, Hung IF, Chen Z, Chen H, Yuen KY. Temporal profiles of viral load in posterior oropharyngeal saliva samples and serum antibody responses during infection by SARS-CoV-2: an observational cohort study. Lancet Infect Dis. 2020 May;20(5):565-574. doi: 10.1016/S1473-3099(20)30196-1. Epub 2020 Mar 23. PMID: 32213337; PMCID: PMC7158907.
13: Chan JF, Yuan S, Kok KH, To KK, Chu H, Yang J, Xing F, Liu J, Yip CC, Poon RW, Tsoi HW, Lo SK, Chan KH, Poon VK, Chan WM, Ip JD, Cai JP, Cheng VC, Chen H, Hui CK, Yuen KY. A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster. Lancet. 2020 Feb 15;395(10223):514-523. doi: 10.1016/S0140-6736(20)30154-9. Epub 2020 Jan 24. PMID: 31986261; PMCID: PMC7159286.
2019
1: Yan B, Zou Z, Chu H, Chan G, Tsang JO, Lai PM, Yuan S, Yip CC, Yin F, Kao RY, Sze KH, Lau SK, Chan JF, Yuen KY. Lipidomic Profiling Reveals Significant Perturbations of Intracellular Lipid Homeostasis in Enterovirus-Infected Cells. Int J Mol Sci. 2019 Nov 26;20(23):5952. doi: 10.3390/ijms20235952. PMID: 31779252; PMCID: PMC6928875.
2: Wang P, Zheng M, Lau SY, Chen P, Mok BW, Liu S, Liu H, Huang X, Cremin CJ, Song W, Chen Y, Wong YC, Huang H, To KK, Chen Z, Xia N, Yuen KY, Chen H. Generation of DelNS1 Influenza Viruses: a Strategy for Optimizing Live Attenuated Influenza Vaccines. mBio. 2019 Sep 17;10(5):e02180-19. doi: 10.1128/mBio.02180-19. PMID: 31530680; PMCID: PMC6751066.
3: Deng J, Wang X, Zhang BZ, Gao P, Lin Q, Kao RY, Gustafsson K, Yuen KY, Huang JD. Broad and Effective Protection against Staphylococcus aureus Is Elicited by a Multivalent Vaccine Formulated with Novel Antigens. mSphere. 2019 Sep 4;4(5):e00362-19. doi: 10.1128/mSphere.00362-19. PMID: 31484738; PMCID: PMC6731528.
4: Lui WY, Yuen CK, Li C, Wong WM, Lui PY, Lin CH, Chan KH, Zhao H, Chen H, To KKW, Zhang AJX, Yuen KY, Kok KH. SMRT sequencing revealed the diversity and characteristics of defective interfering RNAs in influenza A (H7N9) virus infection. Emerg Microbes Infect. 2019;8(1):662-674. doi: 10.1080/22221751.2019.1611346. PMID: 31084471; PMCID: PMC6534226.
5: Ling L, Wu T, To KKW, Cheung KW, Lui KOL, Niu M, Lam KS, Wang CC, Li J, Wang H, Yuen KY, Chen Z. Vedolizumab-mediated integrin α4β7 blockade does not control HIV-1SF162 rebound after combination antiretroviral therapy interruption in humanized mice. AIDS. 2019 Mar 15;33(4):F1-F12. doi: 10.1097/QAD.0000000000002149. PMID: 30829743.
6: Lam WH, Sze KH, Ke Y, Tse MK, Zhang H, Woo PCY, Lau SKP, Lau CCY, Xu S, Lai PM, Zhou T, Antonyuk SV, Kao RYT, Yuen KY, Hao Q. Talaromyces marneffei Mp1 Protein, a Novel Virulence Factor, Carries Two Arachidonic Acid-Binding Domains To Suppress Inflammatory Responses in Hosts. Infect Immun. 2019 Mar 25;87(4):e00679-18. doi: 10.1128/IAI.00679-18. PMID: 30670555; PMCID: PMC6434130.
7: Liu L, Wei Q, Lin Q, Fang J, Wang H, Kwok H, Tang H, Nishiura K, Peng J, Tan Z, Wu T, Cheung KW, Chan KH, Alvarez X, Qin C, Lackner A, Perlman S, Yuen KY, Chen Z. Anti-spike IgG causes severe acute lung injury by skewing macrophage responses during acute SARS-CoV infection. JCI Insight. 2019 Feb 21;4(4):e123158. doi: 10.1172/jci.insight.123158. PMID: 30830861; PMCID: PMC6478436.
8: Yan B, Chu H, Yang D, Sze KH, Lai PM, Yuan S, Shuai H, Wang Y, Kao RY, Chan JF, Yuen KY. Characterization of the Lipidomic Profile of Human Coronavirus- Infected Cells: Implications for Lipid Metabolism Remodeling upon Coronavirus Replication. Viruses. 2019 Jan 16;11(1):73. doi: 10.3390/v11010073. PMID: 30654597; PMCID: PMC6357182.
9: Yuan S, Chu H, Chan JF, Ye ZW, Wen L, Yan B, Lai PM, Tee KM, Huang J, Chen D, Li C, Zhao X, Yang D, Chiu MC, Yip C, Poon VK, Chan CC, Sze KH, Zhou J, Chan IH, Kok KH, To KK, Kao RY, Lau JY, Jin DY, Perlman S, Yuen KY. SREBP-dependent lipidomic reprogramming as a broad-spectrum antiviral target. Nat Commun. 2019 Jan 10;10(1):120. doi: 10.1038/s41467-018-08015-x. PMID: 30631056; PMCID: PMC6328544.